A Phase 2b / 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate the Efficacy and Safety of CSL300 (Clazakizumab) in Subjects With End Stage Kidney Disease Undergoing Dialysis
Status: Recruiting
Location: See all (362) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Male or female at least 18 years of age
• A diagnosis of ESKD undergoing maintenance dialysis for at least 12 weeks
• Serum hs-CRP ≥ 2.0 mg/L
• A diagnosis of diabetes mellitus OR ASCVD
Locations
United States
Alabama
84000149 - Nephrology Consultants, LLC
RECRUITING
Huntsville
84000340 - DaVita Clinical Research Montgomery
RECRUITING
Montgomery
Arizona
84000178 - Kidney Disease Medical Group
RECRUITING
Glendale
84000552 - AKDHC Medical
RECRUITING
Glendale
84000231 - AKDHC Medical
RECRUITING
Phoenix
84000286 - AKDHC Medical
RECRUITING
Tucson
84000622 - Southern Arizona VA Health Care System
RECRUITING
Tucson
California
84000145 - National Institute of Clinical Research
RECRUITING
Bakersfield
84000151 - National Institute of Clinical Research
RECRUITING
Bakersfield
84000277 - Amicis Research Center
RECRUITING
Beverly Hills
84000241 - California Institute of Renal Research
RECRUITING
Chula Vista
84000462 - Davita Fullerton Dialysis Center
RECRUITING
Fullerton
84000574 - National Institute of Clinical Research, Inc.
RECRUITING
Fullerton
84000152 - National Institute of Clinical Research
RECRUITING
Garden Grove
84000464 - St. Jude Medical Center
RECRUITING
Garden Grove
84000573 - National Institute of Clinical Research, Inc.
RECRUITING
Garden Grove
84000230 - Kidney Disease Medical Group
RECRUITING
Glendale
84000531 - Sherman Medical Group, Inc
RECRUITING
Glendale
84000379 - Renal Consultants Medical Group
RECRUITING
Granada Hills
84000631 - Balboa Research
RECRUITING
La Jolla
84000221 - California Institute of Renal Research
RECRUITING
La Mesa
84000235 - California Institute of Renal Research
RECRUITING
La Mesa
84000198 - Southern California Medical Research Center
RECRUITING
La Palma
84000467 - Southern California Medical Research Center
RECRUITING
La Palma
84000158 - DaVita Carabello Dialysis Center
SUSPENDED
Los Angeles
84000329 - Academic Medical Research Institute
RECRUITING
Los Angeles
84000439 - National Institute of Clinical Research, Inc.
RECRUITING
Los Angeles
84000175 - Renal Medical Associates/NARI
RECRUITING
Lynwood
84000279 - Amicis Research Center
RECRUITING
Northridge
84000533 - FORMAT Medical Research
RECRUITING
Oxnard
84000228 - National Nephrology Alliance Research - Riverside
RECRUITING
Riverside
84000331 - Van Buren Dialysis Center
RECRUITING
Riverside
84000492 - Central Coast Nephrology Medical Corp
RECRUITING
Salinas
84000143 - California Institute of Renal Research
SUSPENDED
San Diego
84000238 - California Institute of Renal Research
RECRUITING
San Diego
84000330 - North America Research Institute
RECRUITING
San Dimas
84000341 - North America Research Institute
RECRUITING
San Dimas
84000281 - Satellite Healthcare
SUSPENDED
San Jose
84000440 - Nephrology Educational Services
RECRUITING
Tarzana
84000536 - Valiance Clinical Research
RECRUITING
Tarzana
84000278 - Amicis Research Center
RECRUITING
Vacaville
84000174 - DaVita Vista Del Sol Dialysis
RECRUITING
Victorville
84000323 - National Institute of Clinical Research, Inc
RECRUITING
Victorville
Colorado
84000589 - Western Nephrology
RECRUITING
Arvada
84000223 - Colorado Kidney Care
RECRUITING
Denver
84000454 - Kidney Associates of Colorado, P.C.
RECRUITING
Denver
Connecticut
84000176 - Greater Hartford Nephrology, LLC
RECRUITING
Bloomfield
84000173 - Nephrology and Hypertension Associates PC
RECRUITING
Middlebury
Delaware
84000494 - Nephrology Associates (Delaware)
RECRUITING
Newark
Florida
84000441 - Boca Raton Regional - Research Physicians Network Alliance
RECRUITING
Boca Raton
84000779 - Nova Clinical Research, LLC
RECRUITING
Bradenton
84000661 - Access Research Institute
RECRUITING
Brooksville
84000193 - Horizon Research Group LLC
RECRUITING
Coral Gables
84000443 - South Florida Nephrology Group, PA
RECRUITING
Coral Springs
84000597 - Family First Medical Research Center
RECRUITING
Hialeah Gardens
84000406 - Elixia Pines
RECRUITING
Hollywood
84000650 - Advanced Medical Research Group
RECRUITING
Hollywood
84000140 -South Florida Research Institute
RECRUITING
Lauderdale Lakes
84000599 - South Florida Research Organization LLC
RECRUITING
Medley
84000182 - Nephrology Associates of South Miami
RECRUITING
Miami
84000362 - Kidney and Hypertension Specialists of Miami
RECRUITING
Miami
84000495 - Total Research Group, LLC
RECRUITING
Miami
84000663 - Iconic Clinical Research Center
RECRUITING
Miami
84000527 - Floridian Clinical Research
RECRUITING
Miami Lakes
84000400 - Elixia Central Florida
RECRUITING
Orlando
84000139 - Genesis Clinical Research
SUSPENDED
Tampa
84000532 - Florida Kidney Specialists
RECRUITING
Temple Terrace
84000426 - Florida Premier Research Institute
RECRUITING
Winter Park
Georgia
84000366 - Southwest Georgia Nephrology Clinic
RECRUITING
Albany
84000326 - Coastal Medical Research, LLC
RECRUITING
Brunswick
84000157 - Renal Associates LLC
RECRUITING
Columbus
84000327 - American Clinical Trials
RECRUITING
Douglasville
84000582 - Georgia Nephrology
RECRUITING
Lawrenceville
84000194 - Atekha Nephrology Clinic LLC
COMPLETED
Statesboro
Iowa
84000534 - Dunes Clinical Research LLC
RECRUITING
Sioux City
Indiana
84000528 - NANI Research
RECRUITING
Fort Wayne
84000453 - Nephrology Physician's LLC
RECRUITING
Mishawaka
Kansas
84000374 - Kansas Nephrology Physicians, PA
RECRUITING
Wichita
Kentucky
84000554 - Nephrology Associates of Kentuckiana, PSC
RECRUITING
Louisville
Louisiana
84000550 - Renal Associates of Baton Rouge
RECRUITING
Baton Rouge
Massachusetts
84000220 - Massachusetts General Hospital
RECRUITING
Boston
Michigan
84000465 - Paragon Health, Inc
RECRUITING
Kalamazoo
84000408 - Michigan Kidney Consultants, PC
RECRUITING
Pontiac
84000171 - St. Clair Nephrology Research
RECRUITING
Roseville
84000237 - Center for Advanced Kidney Research, PLC
RECRUITING
Saint Clair Shores
Minnesota
84000146 - DCR Edina
COMPLETED
Minneapolis
84000338 - DCR Edina
RECRUITING
Minneapolis
Missouri
84000147 - Clinical Research Consultants
RECRUITING
Kansas City
84000377 - DCI-Rockhill
RECRUITING
Kansas City
Mississippi
84000225 - Southwest Mississippi Nephrology PLLC
COMPLETED
Brookhaven
84000153 - Nephrology Associates, PC
RECRUITING
Columbus
84000144 - Nephrology and Hypertension Associates Ltd
RECRUITING
Tupelo
North Carolina
84000191 - Metrolina Nephrology Associates, PA
RECRUITING
Charlotte
84000150 - Durham Nephrology Associates, PA
RECRUITING
Durham
84000232 - East Carolina University
RECRUITING
Greenville
84000410 - North Carolina Nephrology, PA
RECRUITING
Raleigh
Nebraska
84000328 - GSR Enterprises, Inc.
RECRUITING
Lincoln
84000222 - Great Plains Health - Nephrology
RECRUITING
North Platte
New Hampshire
84000141 - Seacoast Kidney and Hypertension Specialists
RECRUITING
Portsmouth
New Jersey
84000436 - Hypertension & Nephrology Association
RECRUITING
Eatontown
84000452 - New Jersey Kidney Care
RECRUITING
Jersey City
Nevada
84000420 - DaVita Clinical Research - Henderson
RECRUITING
Henderson
84000337 - Kidney Specialists of Southern Nevada
RECRUITING
Las Vegas
84000148 - Sierra Nevada Specialty Care
RECRUITING
Reno
New York
84000184 - Mattoo & Bhat Medical Associates, P.C.
RECRUITING
College Point
84000393 - NYU Langone Hospital - Long Island
RECRUITING
Mineola
84000155 - DaVita Clinic Research Bronx
COMPLETED
The Bronx
84000276 - Albert Einstein College of Medicine - Montefiore Medical Center
RECRUITING
The Bronx
Ohio
84000548 - HNC Dialysis, Ltd.
RECRUITING
Columbus
Pennsylvania
84000234 - Northeast Clinical Research Center, LLC
RECRUITING
Bethlehem
South Carolina
84000192 - Columbia Nephrology
RECRUITING
Columbia
84000229 - DaVita Clinical Research
RECRUITING
Spartanburg
84000367 - Dialysis Clinic, Inc.
RECRUITING
Spartanburg
Tennessee
84000547 - Southeast Renal Research Institute
RECRUITING
Chattanooga
84000180 - Knoxville Kidney Center PLLC
RECRUITING
Knoxville
84000361 - Dialysis Clinic Inc - University Nephology
RECRUITING
Knoxville
Texas
84000438 - Research Management, Inc.
RECRUITING
Austin
84000451 - Cussimanio Research Group LLC
RECRUITING
Austin
84000549 - MW Clinical Research Center
RECRUITING
Beaumont
84000457 - US Renal Care
RECRUITING
Dallas
84000354 - Davita Clinical Research
RECRUITING
El Paso
84000421 - DaVita Clinical Research - Horizon
RECRUITING
El Paso
84000458 - Fort Worth Renal Group
RECRUITING
Fort Worth
84000196 - Southwest Houston Research
RECRUITING
Houston
84000350 - DaVita Clinical Research
RECRUITING
Houston
84000360 - Clinical Research Strategies, Inc.
RECRUITING
Houston
84000450 - Houston Medical Research Institute, LLC
RECRUITING
Houston
84000498 - DaVita Clinical Research
RECRUITING
Houston
84000598 - Aqua Research Institute
RECRUITING
Houston
84000649 - Clinical Research Strategies
RECRUITING
Houston
84000880 - Laguna Clinical Research Associates, LLC
RECRUITING
Laredo
84000634 - Prime Clinical Research, Inc.
RECRUITING
Mansfield
84000373 - Gamma Medical Research, Inc.
RECRUITING
Mcallen
84000324 - National Institute of Clinical Research, Inc.
RECRUITING
San Antonio
84000351 - DaVita Clinical Research
RECRUITING
San Antonio
84000419 - Davita Clinical Research
RECRUITING
San Antonio
84000553 - DCR-San Antonio Stone Oak
RECRUITING
San Antonio
84000339 - DaVita Clinical Research North Houston
RECRUITING
Shenandoah
84000660 - Medrasa Clinical Research
RECRUITING
Sherman
84000551 - Renal Research of Montgomery County
RECRUITING
The Woodlands
Virginia
84000535 - DCR-Norfolk Great Bridge
RECRUITING
Chesapeake
84000424 - Nephrology Associates of Northern Virginia Inc
RECRUITING
Fairfax
84000138 - Peninsula Kidney Associates
RECRUITING
Hampton
84000156 - Tidewater Kidney Specialists
RECRUITING
Norfolk
West Virginia
84000336 - Nephrology and Hypertension Associates
RECRUITING
Bluefield
Other Locations
Australia
03600056 - Wide Bay Hospital and Health Service
RECRUITING
Bundaberg
03600037 - Cairns Hospital
RECRUITING
Cairns
03600013 - Monash Medical Centre
RECRUITING
Clayton
03600060 - Austin Hospital
RECRUITING
Heidelberg
03600050 - Fiona Stanley Hospital
RECRUITING
Murdoch
03600021 - Sunshine Coast University Private Hospital
SUSPENDED
Nambour
03600021 - Sunshine Coast University Private Hospital
RECRUITING
Nambour
03600041 - Royal Melbourne Hospital
RECRUITING
Parkville
03600023 - Royal North Shore Hospital (RNSH)
RECRUITING
Saint Leonards
03600020 - Gold Coast University Hospital
RECRUITING
Southport
03600011 - Sunshine Hospital
SUSPENDED
St Albans
03600011 - Sunshine Hospital
RECRUITING
St Albans
03600017 - Concord Repatriation General Hospital
RECRUITING
Sydney
03600038 - Fraser Coast Renal Service, Hervey Bay Hospital
RECRUITING
Urraween
03600058 - Sydney Adventist Hospital
RECRUITING
Wahroonga
03600012 - Westmead Hospital
RECRUITING
Westmead
03600048 - Wollongong Renal Unit
RECRUITING
Wollongong
03600014 - Princess Alexandra Hospital
SUSPENDED
Woolloongabba
Austria
04000006 - Wiener Gesundheitsverbund - Klinik Hietzing
RECRUITING
Vienna
Belgium
05600011 - Onze-Lieve-Vrouwziekenhuis VZW
RECRUITING
Aalst
05600011 - Onze-Lieve-Vrouwziekenhuis VZW
SUSPENDED
Aalst
05600005 - Imelda Ziekenhuis
SUSPENDED
Bonheiden
05600004 - AZ Sint-Lucas
SUSPENDED
Ghent
05600013 - Centre Hospitalier Universitaire de Tivoli
RECRUITING
La Louvière
05600012 - Universitair Ziekenhuis Leuven
RECRUITING
Leuven
05600003 - CHR de la Citadelle
SUSPENDED
Liège
05600003 - CHR de la Citadelle
RECRUITING
Liège
05600018 - AZ Delta (H.-Hartziekenhuis Roeselare-Menen vzw (HHRM)) - Campus Rumbeke
RECRUITING
Roeselare
05600014 - VITAZ, Department Nierziekten & Dialyse
RECRUITING
Sint-niklaas
Bulgaria
10000004 - Multiprofile Hospital For Active Treatment Dr Tota Venkova
RECRUITING
Gabrovo
10000002 - Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz - LOM EOOD
RECRUITING
Lom
10000007 - UMHAT Plovdiv
RECRUITING
Plovdiv
10000009 - University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
RECRUITING
Plovdiv
10000011 - Multiprofile Hospital for Active Treatment Dr. Ivan Seliminski - Sliven AD
RECRUITING
Sliven
10000001 - Medical Center - Smolyan OOD
RECRUITING
Smolyan
10000005 - Dialysis Center VIA DIAL OOD
RECRUITING
Stara Zagora
10000008 - UMHAT Prof. Dr. Stoyan Kirkovich
RECRUITING
Stara Zagora
Canada
12400008 - University of Alberta Hospital
RECRUITING
Edmonton
12400008 - University of Alberta Hospital
RECRUITING
Edmonton
12400021 - Queen Elizabeth II Health Sciences Centre
RECRUITING
Halifax
12400026 - St. Josephs Healthcare Hamilton
RECRUITING
Hamilton
12400009 - Kingston Health Sciences Centre
RECRUITING
Kingston
12400030 - London Health Sciences Centre - University Hospital
RECRUITING
London
12400014 - Maisonneuve-Rosemont Hospital
RECRUITING
Montreal
12400015 - Hôpital du Sacré-Cœur-de-Montréal
RECRUITING
Montreal
12400023 - McGill University Health Centre
RECRUITING
Montreal
12400031 - CHUM - Centre hospitalier de l'Universite de Montreal
RECRUITING
Montreal
12400024 - Lakeridge Health Oshawa
RECRUITING
Oshawa
12400048 - Ciussse-Chus
RECRUITING
Sherbrooke
12400032 - St. Michaels Hospital
RECRUITING
Toronto
12400016 - St Paul Hospital
RECRUITING
Vancouver
12400027 - Seven Oaks Hospital
RECRUITING
Winnipeg
China
15600014 - Peking University First Hospital
RECRUITING
Beijing
15600036 - Beijing Tsinghua Chang Gung Hospital
RECRUITING
Beijing
15600053 - People's Hospital of Deyang
RECRUITING
Deyang Shi
15600033 - Anhui Medical University-The Second Hospital
RECRUITING
Hefei
15600019 - Gansu Provincial People's Hospital
RECRUITING
Lanzhou
15600045 - Nanchang University - The First Affiliated Hospital
RECRUITING
Nanchang
15600052 - The People's Hospital Guangxi Zhuang of Autonomous Region
RECRUITING
Nanning
15600035 - Southern Medical University - Jiangxi Pingxiang People's Hospital
RECRUITING
Pingxiang
15600034 - Shanghai Jiao Tong University School of Medicine (SJTUSM)-Renji Hospital
RECRUITING
Shanghai
15600030 - Shanghai First People's Hospital
RECRUITING
Shanghai Shi
15600049 - Shijiazhuang People's Hospital
RECRUITING
Shijiazhuang
15600038 - Second Hospital of Shanxi Medical University
RECRUITING
Taiyuan
15600044 - Tianjin People's Hospital
RECRUITING
Tianjin
15600037 - Huazhong University of Science and Technology - Tongji Medical College - The Central Hospital of Wuhan (Wuhan Second Hospital)
RECRUITING
Wuhan
15600015 - Wuxi People's Hospital
RECRUITING
Wuxi
15600018 - Zhongshan Hospital Xiamen University
RECRUITING
Xiamen
15600040 - Yan'an University Xianyang Hospital
RECRUITING
Xianyang
15600029 - Xinxiang City First People's Hospital
RECRUITING
Xinxiang
15600022 - Northern Jiangsu People's Hospital
RECRUITING
Yangzhou
15600025 - Yibin Second People's Hospital
RECRUITING
Yibin
15600026 - Affiliated Hospital of Jiangsu University
RECRUITING
Zhenjiang
Denmark
20800009 - Aalborg Universitetshospital
RECRUITING
Aalborg
20800010 - Herlev Hospital
RECRUITING
Herlev
20800008 - Gødstrup Hospital
RECRUITING
Herning
20800011 - Trail Nation: Nordsjællands Hospital
RECRUITING
Hillerød
France
25000011 - CHU Amiens - Nephrology Dialysi Transplantation Department
RECRUITING
Amiens
25000014 - CHU de Saint-Étienne - Hôpital Nord
RECRUITING
Aura
25000027 - Centre Hospitalier Regional Universitaire (CHRU) Brest - Hopital de la Cavale Blanche
RECRUITING
Brest
25000013 - CHU de Caen
RECRUITING
Caen
25000032 - Fondation Charles Mion AIDER Santé
RECRUITING
Grabels
25000026 - Hopital Prive La Louviere
RECRUITING
Lille
25000033 - CHU de Limoges
RECRUITING
Limoges
25000018 - Centre Hospitalier Universitaire Montpellier - Hôpital Lapeyronie
RECRUITING
Montpellier
25000020 - CHU de Nimes - Hopital Universitaire Caremeau
RECRUITING
Nîmes
25000025 - AURA Paris - Plaisance
RECRUITING
Paris
25000028 - Hopital Pitie-Salpetriere
RECRUITING
Paris
25000019 - Centre Hospitalier Universitaire (CHU) de Reims - Hopital Maison Blanche
RECRUITING
Reims
25000016 - AURA St Quen Dialysis centre
RECRUITING
Saint-ouen
25000029 - Hôpitaux Universitaires de Strasbourg - Hôpital Civil
RECRUITING
Strasbourg
25000012 - CHU Rangueil
RECRUITING
Toulouse
Germany
27600047 - Charite-Universitatsmedizin Berlin
RECRUITING
Berlin
27600041 - Nierenzentrum Bad König
RECRUITING
Hessen
27600039 - Westpfalz Klinikum GmbH
RECRUITING
Kaiserslautern
27600022 - UKSH - Universitatsklinik Schleswig-Holstein
SUSPENDED
Kiel
27600021 - Kuratorium fuer Dialyse und Nierentransplantation e.V. - KfH-Nierenzentrum - St. Georg
RECRUITING
Leipzig
27600040 - Universitätsmedizin der Johannes Gutenberg-Universität Mainz
RECRUITING
Mainz
27600020 - Nephrologisches Zentrum Villingen-Schwenningen
SUSPENDED
Villingen-schwenningen
27600020 - Nephrologisches Zentrum Villingen-Schwenningen
RECRUITING
Villingen-schwenningen
Greece
30000015 - University Hospital of Alexandroupolis
RECRUITING
Alexandroupoli
30000016 - General Hospital of Arta
RECRUITING
Arta
30000012 - University General Hospital of Heraklion
RECRUITING
Crete
30000002 - General Hospital of Ioannina G. Hatzikosta
RECRUITING
Ioannina
30000004 - University General Hospital of Ioannina
RECRUITING
Ioannina
30000014 - Nephrological Clinic University Hospital, University of Thessaly
RECRUITING
Larissa
30000013 - General Hospital of Ptolemaida
RECRUITING
Ptolemaida
30000008 - University Hospital of Patras
RECRUITING
Rio
30000003 - AHEPA Univ. Hospital, Medical School, Aristotle University of Thessaloniki
RECRUITING
Thessaloniki
30000005 - Aristotle University, Hippokration
RECRUITING
Thessaloniki
30000006 - General Hospital of Thessaloniki, Agios Pavlos
RECRUITING
Thessaloniki
30000009 - Papageorgiou General Hospital of Thessaloniki
RECRUITING
Thessaloniki
30000011 - Nephrology Department G. Papanikolaou General Hospital
RECRUITING
Thessaloniki
Hungary
34800012 - B. Braun Avitum - 14. Dialízisközpont Kistarcs
RECRUITING
Kistarcsa
Israel
37600008 - Carmel Medical Center
RECRUITING
Haifa
37600012 - Edith Wolfson Medical Center
RECRUITING
Holon
37600010 - Rabin Medical Center
RECRUITING
Petah Tikva
37600011 - Chaim Sheba Medical Center (Sheba Tel-Hashomer Medical Center )
RECRUITING
Ramat Gan
37600013 - Ziv Medical Center
RECRUITING
Safed
37600009 - Ichilov Hospital-Tel-Aviv Sourasky Medical Center
RECRUITING
Tel Aviv
37600002 - Medical Research & Development Fund for Health Services, PORIYA Hospital
RECRUITING
Tiberias
Italy
38000025 - ASST degli Spedali Civili di Brescia
RECRUITING
Brescia
38000031 - Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta
RECRUITING
Caserta
38000034 - AOU Policlinico G Rodolico - San Marco - Presidio Ospedaliero ospedale San Marco
RECRUITING
Catania
38000061 - Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna
RECRUITING
Ferrara
38000074 - Ospedale Santa Maria Annunziata
RECRUITING
Florence
38000027 - A. O. -Universitaria Ospedali Riuniti di Foggia Farmacia Osp
RECRUITING
Foggia
38000059 - IRCCS Az. Osp. Universitaria San Martino- IST
RECRUITING
Genova
38000063 - Vito Fazzi Hospital in Lecce
RECRUITING
Lecce
38000024 - ASST di Lecco - Presidio Ospedaliero A. Manzoni di Lecco
RECRUITING
Lecco
38000029 - Università degli Studi di Messina
RECRUITING
Messina
38000017 - ASST Santi Paolo e Carlo - Ospedale San Carlo Borromeo
RECRUITING
Milan
38000023 - IRCCS Ospedale San Raffaele
RECRUITING
Milan
38000069 - Ospedale Maggiore di Novara
RECRUITING
Novara
38000019 - ICS Maugeri S.p.A. SB; Università di Pavia; Fondazione Salvatore Maugeri IRCCS
RECRUITING
Pavia
38000026 - University of Verona
RECRUITING
Peschiera Del Garda
38000064 - AUSL Piacenza Hospital-Unit Nephrology Dialysis, Dept of Medicine
RECRUITING
Piacenza
38000032 - Ospedale Santo Stefan
RECRUITING
Prato
38000060 - Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
RECRUITING
Reggio Calabria
38000067 - Rimini Hospital
RECRUITING
Rimini
38000016 - Ospedale Casa Sollievo della Sofferenza (CSS)
RECRUITING
San Giovanni Rotondo
38000020 - Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
RECRUITING
Verona
Japan
39200042 - Matsunami General Hospital
RECRUITING
Hashima-gun
39200041 - Ishikiriseiki Hospital
RECRUITING
Higashiosaka-shi
39200055 - Miki Internal Medicine Urology Clinic
RECRUITING
Hokkaido
39200053 - Daiyukai Daiichi Hospital
RECRUITING
Ichinomiya-shi
39200033 - Tokyo Medical University Ibaraki Medical Center
RECRUITING
Inashiki-gun
39200043 - Ueyama Hospital
RECRUITING
Kagoshima
39200046 - Steel Memorial Yawata Hospital
RECRUITING
Kitakyushu-shi
39200021 - Kurume University Hospital
RECRUITING
Kurume
39200038 - St. Mary's Hospital
RECRUITING
Kurume-shi
39200054 - Omi freai Hospital
RECRUITING
Kusatsu-shi
39200028 - Rakuwakai Otowa Kinen Hospital
RECRUITING
Kyoto
39200048 - Maebashi Hirosegawa Clinic
RECRUITING
Maebashi
39200049 - Joumou Ohashi Clinic
RECRUITING
Maebashi
39200037 - Nagaoka Red-Cross Hospital
RECRUITING
Nagaoka-shi
39200020 - Chubu Rosai Hospital
RECRUITING
Nagoya
39200035 - Daido Hospital
RECRUITING
Nagoya
39200026 - Omihachiman Community Medical Center - Kidney Center
RECRUITING
Ōmihachiman
39200032 - Oguranaika Jin Cinic
RECRUITING
Oyama-shi
39200029 - Ibaraki Seinan Medical Center Hospital
RECRUITING
Sakaimachi
39200045 - Teine Urological Clinic
RECRUITING
Sapporo
39200027 - Tokyo Womens Med University
RECRUITING
Shinjuku-ku
39200031 - Kurosawa Hospital
RECRUITING
Takasaki-shi
39200034 - Kikuchi Medical Clinic
RECRUITING
Tsukuba
39200030 - St.Hill Hospital
RECRUITING
Ube-shi
39200044 - Juntendo University Urayasu Hospital
RECRUITING
Urayasu-shi
39200051 - Bosei Kannai Clinic
RECRUITING
Yokohama
39200036 - Sanin Rosai Hospital
RECRUITING
Yonago-shi
Norway
57800004 - Vestre Viken HF - Drammen Sykehus (Sykehuset Buskerud)
RECRUITING
Drammen
Poland
61600011 - Powiatowy Szpital Specjalistyczny w Stalowej Woli
RECRUITING
Stalowa Wola
61600022 - Diaverum - NZOZ Tczewie
RECRUITING
Tczew
61600025 - DaVita Stacja Dializ
RECRUITING
Warsaw
Portugal
62000011 - Unidade Local de Saúde de Braga, E. P. E.
RECRUITING
Braga
62000010 - Unidade Local de Saúde de Loures -Odivelas, E. P. E.
RECRUITING
Loures
62000009 - Unidade Local de Saúde de São José, E. P. E.
RECRUITING
Oeiras
62000005 - Unidade Local de Saúde de Santo António, E. P. E.
RECRUITING
Porto
62000007 - Unidade Local de Saúde do Estuário do Tejo, E. P. E.
RECRUITING
Vila Franca De Xira
Republic of Korea
41000006 - Hallym University Sacred Heart Hospital
RECRUITING
Anyang-si
41000004 - Keimyung University Dongsan Medical Center
RECRUITING
Daegu
41000001 - Gangnam Severance Hospital
RECRUITING
Gangnam-gu
41000009 - National Health Insurance Service - Ilsan Hospital
RECRUITING
Goyang-si
41000010 - Hanyang University Guri Hospital
RECRUITING
Guri-si
41000008 - Konkuk University Medical Center
RECRUITING
Gwangju
41000002 - SMG - SNU Boramae Medical Center
RECRUITING
Ilsan-gu
41000005 - Seoul National University Hospital
RECRUITING
Seoul
41000012 - Severance Hospital, Yonsei University
RECRUITING
Seoul
41000007 - Yonsei University - Wonju Severance Christian Hospital
RECRUITING
Wŏnju
Romania
64200014 - SC International Healthcare Systems SA - IHS Sf. Ioan Dialysis Center
RECRUITING
Bucharest
64200024 - Fundeni Clinical Institute
RECRUITING
Bucharest
64200016 - Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta)
RECRUITING
Constanța
64200026 - Spitalul Clinic -Dr. C.I. Parhon - Iasi
RECRUITING
Iași
64200005 - Spital Judetean de Urgenta Satu Mare
RECRUITING
Satu Mare
Slovakia
70300002 - LC-REN s.r.o.
RECRUITING
Lučenec
Spain
72400019 - Hospital Universitari de Girona Dr Josep Trueta, (Avitum)
RECRUITING
Girona
72400011 - Universidad de Alcala (UAH)
RECRUITING
Guadalajara
72400007 - Hospital Universitari Arnau de Vilanova
RECRUITING
Lleida
72400012 - Hospital de Manises
RECRUITING
Manises
72400008 - Hospital Universitari i Politècnic La Fe
RECRUITING
Valencia
72400031 - Hospital Clinico Universitario - Valencia
RECRUITING
Valencia
Sweden
75200001 - Uppsala Universitet - Akademiska Sjukhuset
RECRUITING
Uppsala
United Kingdom
82600041 - University Hospitals Birmingham NHS Foundation Trust - Birmingham Heartlands Hospital (BHH)
RECRUITING
Birmingham
82600027 - Bradford Teaching Hospitals NHS Foundation Trust
RECRUITING
Bradford
82600023 - University Hospital Coventry and Warwickshire
RECRUITING
Coventry
82600060 - University Hospitals of Derby and Burton NHS Foundation Trust - Royal Derby Hospital
RECRUITING
Derby
82600022 - Dorset County Hospital NHS Foundation Trust - Dorset County Hospital (DCH)
RECRUITING
Dorchester
82600024 - Royal Liverpool University Hospital
RECRUITING
Liverpool
82600026 - William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital
RECRUITING
London
82600026 - William Harvey Research Institute ; Barts Health NHS Trust - The Royal London Hospital
RECRUITING
London
82600032 - King´s College NHS Trust
RECRUITING
London
82600034 - St George's University Hospitals NHS Foundation Trust - St G
RECRUITING
London
82600042 - Hammersmith Hospital Imperial College Healthcare NHS Trust -Hammersmith Hospital - West London Renal and Transplant Centre
RECRUITING
London
82600028 - Altnagelvin Area Hospital
RECRUITING
Londonderry
82600029 - Northern Care Alliance NHS Foundation Trust - Salford Royal NHS Foundation Trust-Salford Care Organisation
RECRUITING
Salford
82600039 - The Shrewsbury and Telford Hospital NHS Trust (SaTH) - Royal Shrewsbury Hospital
RECRUITING
Shrewsbury
82600025 - Royal Stoke University Hospital
RECRUITING
Stoke-on-trent
82600049 - The Royal Wolverhampton NHS Trust - New Cross Hospital
RECRUITING
Wolverhampton
Contact Information
Primary
Trial Registration Coordinator
clinicaltrials@cslbehring.com
+1 610-878-4697
Time Frame
Start Date: 2022-10-21
Estimated Completion Date: 2029-08-30
Participants
Target number of participants: 2310
Treatments
Experimental: CSL300 (low dose)(Phase 2b)
Intravenous (IV) administration
Experimental: CSL300 (medium dose)(Phase 2b)
IV administration
Experimental: CSL300 (high dose)(Phase 2b)
IV administration
Placebo_comparator: Placebo (Phase 2b)
IV administration
Experimental: CSL300 (Phase 3)
IV administration
Placebo_comparator: Placebo (Phase 3)
IV administration
Related Therapeutic Areas
Sponsors
Leads: CSL Behring